Mycobacterial Infections Associated with TNF-α Inhibitors
نویسندگان
چکیده
منابع مشابه
Relationship of bovine TNF-α gene polymorphisms with the risk of bovine tuberculosis in Holstein cattle
Many studies suggest significant genetic variation in the resistance of cattle and humans to infection with Mycobacterium bovis (M. bovis), the causative agent of zoonotic tuberculosis. TNF-α promotes inflammation and induces apoptosis in response to mycobacterial infection. The aim of the present study was to investigate the influence of single nucleotide polymorphisms of the TNF-α gene on bov...
متن کاملAssociation between tumour necrosis factor-α inhibitors and risk of serious infections in people with inflammatory bowel disease: nationwide Danish cohort study
OBJECTIVE To investigate whether people with inflammatory bowel disease treated with tumour necrosis factor-α (TNF-α) inhibitors are at increased risk of serious infections. DESIGN Nationwide register based propensity score matched cohort study. SETTING Denmark, 2002-12. PARTICIPANTS The background cohort eligible for matching comprised 52,392 people with inflammatory bowel disease, aged ...
متن کاملFunctional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load.
High Ag load in chronic viral infections has been associated with impairment of Ag-specific T cell responses; however, the relationship between Ag load in chronic Mycobacterium tuberculosis infection and functional capacity of M. tuberculosis-specific T cells in humans is not clear. We compared M. tuberculosis-specific T cell-associated cytokine production and proliferative capacity in peripher...
متن کاملAssessment of the Effects of Cyclooxygenase Inhibitors on the Immune Status Following Surgery in Adult Male Rats
Background and Objectives: Surgery via different mechanisms causes immunosuppression in the post-operative period. The aim of the present study was to investigate the effects of preoperative administration of cyclooxygenase inhibitors on blood levels of Interleukin-2 (IL-2), Interferon-γ (IFN-γ), Tumor Necrosis Factor-α (TNF-α), white blood cells (WBCs) and lymphocytes. Methods: Seventy-five ma...
متن کاملفاکتور نکروزدهنده تومور آلفا و راهکارهای مهار آن: مقاله مروری
Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine produced by a variety of cells, including hematopoietic and non-hematopoietic cells, malignant cells, macrophages, B lymphocytes, T lymphocytes, natural killer cells, neutrophils, astrocytes, endothelial cells, and smooth muscle cells. TNF-α is a homo-trimeric molecular whose individual subunits are composed of antiparallel beta...
متن کامل